HEALTH & FITNESS
This human heart-muscle patch can boost heart attack recovery
Novel heart-muscle patches made with human cells can significantly improve recovery from a heart attack, results of a clinical trial show.
The results are a step closer to the goal of treating human heart attacks by suturing cardiac-muscle patches over an area of dead heart muscle in order to reduce the pathology that often leads to heart failure, said scientists led by Jianyi "Jay" Zhang, Chair of University of Alabama at Birmingham.
In the study, described in the journal Circulation, the team tested human cardiac-muscle patches of 1.57 by 0.79 inches in size and nearly as thick as a dime, created in the lab, on large animals in a heart attack model.
Transplanting two of these patches onto the infarcted area of a pig heart significantly improved function of the heart's left ventricle, the major pumping chamber.
The patches also significantly reduced infarct size, which is the area of dead muscle, heart-muscle wall stress and heart-muscle enlargement, as well as significantly reducing apoptosis, or programmed cell death, in the scar boarder area around the dead heart muscle.
Furthermore, the patches did not induce arrhythmia in the hearts -- improper beating of the heart, too fast or too slow.
Each patch was made from a mixture of three cell types -- four million cardiomyocytes, or heart-muscle cells, two million endothelial cells -- known to help cardiomyocytes survive and function in a micro-environment -- and two million smooth muscle cells, which line blood vessels.
Each patch was grown in a three-dimensional fibrin matrix that was rocked back and forth for a week. The cells begin to beat synchronously after one day.
This mixture of three cell types and the dynamic rocking produced more heart muscle cells that were more mature, with superior heart-muscle physiological function and contractive force.
The patches resembled native heart-muscle tissue in their physiological and contractile properties, the scientists noted.
- HC notice on plea regarding cruelty on dairy cattle 17 Jan 2018 | IANS
- Eating high-salt diet may lead to dementia 17 Jan 2018 | IANS
- Curbing junk food ads may cut rising obesity in teens 17 Jan 2018 | IANS
- High fat western diet could make prostate cancer aggressive 16 Jan 2018 | IANS
- Benefits of sesame seeds for skin, health 16 Jan 2018 | IANS
- Humans share fish genes that aid in repairing spinal cord 16 Jan 2018 | IANS
- Sexual crimes in neighbourhood may harm women's mental health 15 Jan 2018 | PTI
- Bullied kids at high risk of anxiety, suicidal behaviour 15 Jan 2018 | IANS
- Genes that may lead to obesity identified 15 Jan 2018 | IANS
- Fast food may make immune system more aggressive: study 14 Jan 2018 | PTI
Sunday EditionView All
14 Jan 2018 | AFP | Yangon
Myanmar’s civilian leader Aung San Suu Kyi has welcomed an unprecedented army admission that security forces carried out extra-judicial killings of Rohingya Muslims as a “positive step”, state-backed media reported on Saturday. After months of staunch denials of abuse, the army on Wednesday said a probe found four members of the security forces helped kill 10 Rohingya militant suspects at Inn Din village on September 2, leaving their bodies in a...
STATE EDITIONSView All
18 Jan 2018 | PNS | BHUBANESWAR
The Sambalpur University and Birla Global University (BGU) registered contrasting victories on the second day of the ongoing SOA Premier League (SPL) T-20 cricket championship at the SOA Stadium here on Wednesday. The Sambalpur crushed IIT, Bhubaneswar by 10 wickets in a group-D match, while the BGU struggled to secure a narrow five run victory over IIIT in a Group-B tie...