Biochemical markers in synovial fluid can help estimate time since death

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Biochemical markers in synovial fluid can help estimate time since death

Wednesday, 31 May 2023 | Staff Reporter | BHOPAL

A groundbreaking cross-sectional comparative study conducted at the Department of Forensic Medicine and Toxicology, AIIMS Bhopal, in collaboration with the Department of Biochemistry, has shed light on a new approach to estimating the time since death. The study, spanning over two years with a sample size of 60 deceased bodies, has successfully correlated biochemical parameters in synovial fluid with known time since death. The findings have the potential to significantly enhance forensic investigations and contribute to more accurate estimations of the post-mortem interval.

Led by Dr. Raghvendra Kumar Vidua, Additional Professor of Forensic Medicine & Toxicology, along with Dr. Ashok Kumar, Additional Professor of Biochemistry, Dr. Atul Keche, Associate Professor of Forensic Medicine & Toxicology, and Dr. Poova Raghavan, Junior Resident of Forensic Medicine & Toxicology, the study was meticulously conducted following ethical guidelines and obtaining informed consent from the deceased's next of kin.

The research team focused on analyzing the synovial fluid, collected from the knee joint of deceased bodies, to measure specific biochemical parameters including sodium, potassium, lactate, and total proteins. The analysis was carried out using a random access fully automated chemical analyzer. Results demonstrated a significant correlation between the tested biochemical markers, except for synovial sodium, and the time since death.

Notably, potassium and lactate showed a significant positive correlation with time since death, while total proteins exhibited a significant negative correlation. These findings suggest that these markers can be utilized effectively to estimate the time since death, providing forensic investigators with more objective and reliable tools for their analyses.

Dr. Raghvendra Kumar Vidua, the lead researcher, commented, "Our study marks an important milestone in forensic medicine, offering promising insights into estimating the post-mortem interval through biochemical analysis of synovial fluid. These findings have the potential to enhance the accuracy and objectivity of forensic investigations, ultimately aiding law enforcement agencies in solving crimes."

The study, which will soon be published in the esteemed American Journal of Forensic Medicine & Toxicology, calls for further research with larger sample sizes and consideration of additional factors influencing the post-mortem interval to validate and expand upon the findings. The research team's work paves the way for future studies exploring the correlation between lactate and total proteins in body fluids, providing a more comprehensive understanding of their applicability in determining the time since death.

The results of this study hold great promise for the field of forensic medicine, offering a valuable contribution to the advancement of objective and scientifically sound methods for estimating the time since death. With continued research and validation, these findings could potentially revolutionize forensic investigations worldwide.

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