IISER designs modular platform for protein engineering

| | Bhopal
  • 0

IISER designs modular platform for protein engineering

Tuesday, 08 June 2021 | Staff Reporter | Bhopal

Indian Institute of Science Education and Research (IISER) Bhopal researchers have invented a new technology that can deliver active molecules to specific sections of proteins. Scientists from IISER Bhopal have been conducting studies on the ‘engineering’ of protein molecules for the past few years. They have designed the first-ever modular platform for the precision engineering of proteins.

The research team from the Departments of Chemistry and Biological Sciences at IISER Bhopal includes Vishal Rai, Ram Kumar Mishra, Sanjeev Shukla, Srinivasa Rao Adusumalli, Dattatraya Gautam Rawale, and Neetu Kalra, among others who have worked on this novel research.

The development of their Linchpin Directed Modification (LDM) platform has been described in three papers published in the Journal of the American Chemical Society (2018), Angewandte Chemie (International Edition - 2020), and Chemical Science (2021).

Explaining the significance of this research, Vishal Rai, Associate Professor and Swarnajayanti Fellow, Department of Chemistry, IISER Bhopal, said, “Our team believes that successful platforms for precision engineering of proteins depend on the core understanding of molecular and social behaviour of proteins in the chemical reactions.”

“A key advantage of our LDM platform is that it does not modify the structure or functions of the native protein,” explained Rai.“The LDM platform provides unprecedented control over precision in protein engineering and a very powerful chemical toolbox for biology and medicine,” said the lead researcher.

State Editions

Transformed schools in S'garh have no HMs, required teachers

27 November 2021 | MAlAY RAY | Bhubaneswar

Jajpur’s renowned poet D Mallick honoured

27 November 2021 | PNS | Bhubaneswar

Folk artists felicitated in Talcher

27 November 2021 | PNS | Bhubaneswar

Binka farmers spending sleepless nights

27 November 2021 | SRIKUMAR MAHANTA | Bhubaneswar

Sunday Edition

Mapping the Indian travel trend

21 November 2021 | Rajeev Kale | Agenda

Power of Kindness

21 November 2021 | Sant Rajinder Singh | Agenda

Fix your mental health

21 November 2021 | Anamika Yaduvanshi | Agenda

Soul conscious helps

21 November 2021 | Ajit Kumar Bishnoi | Agenda

Astroturf | Can destiny be defined?

21 November 2021 | Bharat Bhushan Padmadeo | Agenda


21 November 2021 | SUPRIYA RAMESH | Sunday Pioneer