Scientists are developing a chewing gum laced with a plant-grown protein that serves as a "trap" for the SARS-CoV-2 virus, which causes Covid-19, reducing viral load in saliva and potentially lowering transmission.
The researchers noted that people who are fully vaccinated can still become infected with SARS-CoV-2 and can carry a viral load similar to those who are unvaccinated.
"SARS-CoV-2 replicates in the salivary glands, and we know that when someone who is infected sneezes, coughs, or speaks some of that virus can be expelled and reach others," said Henry Daniell at the University of Pennsylvania in the US.
"This gum offers an opportunity to neutralise the virus in the saliva, giving us a simple way to possibly cut down on a source of disease transmission," said Daniell, who led the study published in the journal Molecular Therapy.
Prior to the pandemic, Daniell had been studying the angiotensin-converting enzyme 2 (ACE2) protein in the context of treating hypertension.
His lab had grown this protein, as well as many others that may have therapeutic potential, using a patented plant-based production system.
This system has the potential to avoid the usual obstacles to protein drug synthesis: an expensive production and purification process, the researchers said.
